Some applications will no longer function with certain permissions and will no longer function without certain permissions.

In Catalina and higher macOS, how applications manage their permissions as well as how kernel integrations are handled has been changed. Shared folders stop working (if you were using them).Some features such as copy/paste and drag-and-drop between the host OSX and guest Virtual Machine is not working, or causes freezing or crashes.The Virtual Machine freezes seemingly at random or has very slow performance (compared to pre-MacOS upgrade).VirtualBox and/or the Virtual Machine crashes immediately or may crash while your are interacting with the VM or when you deselect the active instance window.

VirtualBox and the Virtual Machines were working fine, but then stopped working after upgrading macOS (to Catalina and newer).

New installations of VirtualBox on newer macOS will install successfully, but attempting to run a Virtual Machine will fail.

The reported issue is happening in at least two circumstances: Multiple people have reported VirtualBox having a variety of issues running VirtualBox and its Virtual Machines on macOS (Catalina and newer). Still Experiencing Problems? Symptoms of the VirtualBox macOS Security and Access Problem

SOLUTION 3: Clean Re-install of VirtualBox.

SOLUTION 2: Modify VirtualBox Permissions.

SOLUTION 1: Allow Identified Apps to Access the System.

Symptoms of the VirtualBox macOS Security and Access Problems

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